Study Links Child Kidney Function Factors


March 19, 2009

Contact: Lauren Cruse (505) 272-3690


Kidney Function, Cause of Kidney Disease, and Race Play Roles

ALBUQUERQUE, N.M.Characteristics associated with proteinuria, presence of protein in urine and a predictor of decline in child kidney function, have been identified in a recent study led by Craig Wong, M.D., MPH, pediatric kidney specialist at the University of New Mexico Children’s Hospital.

The findings indicate that the level of kidney impairment, the cause of kidney disease, and race are linked to proteinuria. The results provide new information regarding the importance of proteinuria and the factors associated with its development in the largest group of children with chronic kidney disease (CKD) ever studied.

In children with CKD, proteinuria has not been extensively studied and researchers have not known what factors are linked to its presence.

To better understand proteinuria in young kidney disease patients, Wong and his colleagues studied subjects enrolled in the Chronic Kidney Disease in Children cohort study, a trial designed to investigate the factors influencing the progression of CKD in children.

More than 400 patients, ages 1 to 16 years, were seen at 43 pediatric nephrology centers across North America. Clinical tests revealed that proteinuria levels were higher in children with low glomerular filtration rates, an indication of low kidney function. Proteinuria was also associated with non-Caucasian race, which suggests that differences in proteinuria might be due to genetic or environmental factors.

The article, entitled “Association of Proteinuria with Race, Cause of Chronic Kidney Disease, and Glomerular Filtration Rate in the Chronic Kidney Disease in Children Study,” will appear in the March 2009 issue of the Clinical Journal of the American Society of Nephrology.

Contact: Lauren Cruse, 272-3322

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