Papers and Publications

Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics

By Prashant Dogra1, Natalie L. Adolphi2, Zhihui Wang 1,3, Yu-Shen Lin4, Kimberly S. Butler5,6,7, Paul N. Durfee 5,8, Jonas G. Croissant 5,6, Achraf Noureddine 5,6, Eric N. Coker 9, Elaine L. Bearer10, Vittorio Cristini1,3 & C. Jeffrey Brinker5,6,8,11 | January 18, 2019
Here, using stable, monosized, radiolabeled, mesoporous silica nanoparticles (MSNs), we apply an integrated SPECT/CT imaging and mathematical modeling approach to understand the combined effects of MSN size, surface chemistry and routes of administration on biodistribution and clearance kinetics in healthy rats.

Urban and Rural Emergency Department Performance on National Quality Metrics for Sepsis Care in the United States | Journal of Rural Health

By Margaret B. Greenwood‐Ericksen, MD, MPH , Craig Rothenberg, MPH, Nicholas Mohr, MD, MS, Shawn D. Andrea, MD, MPH, Todd Slesinger, MD, Tiffany Osborn, MD, MPH, Jessica Whittle, MD, PhD, Pawan Goyal, MD, Nalani Tarrant MPH, Jeremiah D. Schuur, MD, MHS, Donald M. Yealy, MD, Arjun Venkatesh, MD | November 29, 2018
Purpose The Centers for Medicare and Medicaid Services (CMS) and the American College of Emergency Physicians (ACEP) developed national quality measures for emergency department (ED) sepsis care. Like care for many conditions, meeting sepsis quality metrics can vary between settings. We sought to examine and compare sepsis care quality in rural vs urban hospital‐based EDs.